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1.Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer

作者机构:[Shen, Hongbing] Nanjing Med Univ, Dept Epidemiol & Biostat, Ctr Canc, Nanjing 210029, Peoples R Chi...

通讯作者:Hu, ZB;Chen, X;Zhao, Y;Tian, T;Jin, GF;Shu, YQ;Chen, YJ;Xu, L;Zen, K;Zhang, CY;Shen, HB

摘要:Purpose Recent findings that human serum contains stably expressed microRNA (miRNA) have revealed a great potential of serum miRNA signature as disease fingerprints to predict survival. We used genome-wide serum miRNA expression analysis to investigate the role of serum miRNA in predicting prognosis of non-small-cell lung cancer (NSCLC). Patients and Methods To control disease heterogeneity, we us...

2.Genetic variants of miRNA sequences and non-small cell lung cancer survival

作者机构:[Hu, Zhibin; Chen, Jiaping; Tian, Tian; Zhou, Xiaoyi; Miao, Ruifen; Jin, Guangfu; Ma, Hongxia; Shen,...

通讯作者:Hu, ZB;Chen, JP;Tian, T;Zhou, XY;Gu, HY;Xu, L;Zeng, Y;Miao, RF;Jin, GF;Ma, HX;Chen, YJ;Shen, HB

摘要:Recent evidence indicates that small noncoding RNA molecules known as microRNAs (miRNAs) can function as tumor suppressors and oncogenes. Mutation, misexpression, and altered mature miRNA processing are implicated in carcinogenesis and tumor progression. Because SNPs in pre-miRNAs could alter miRNA processing, expression, and/or binding to target mRNA, we conducted a systematic survey of common pr...

3.Long non-coding RNAs: A new frontier in the study of human diseases

作者机构:[Shi, Xuefei; Liu, Hongbing; Yao, Yanwen; Song, Yong] Nanjing Univ, Jinling Hosp, Sch Med, Dept Resp...

通讯作者:Shi, XF;Sun, M;Liu, HB;Yao, YW;Song, Y

关键词:Long non-coding RNAs; Human diseases; Mechanism

摘要:With the development of whole genome and transcriptome sequencing technologies, long noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that lncRNAs act not only as the intermediary between DNA and protein but also as important protagonists of cellular functions. LncRNAs can regulate gene expression in many ways, including chromosome remodeling, transcription and...

4.Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

作者机构:[Gao, Hai-Nv; Yang, Yi-Da; Fang, Qiang; Ruan, Ling-Xiang; Liang, Wei-Feng; Xia, Qi; Feng, Zhi-Xian; ...

通讯作者:Gao, HN;Lu, HZ;Cao, B;Du, B;Shang, H;Gan, JH;Lu, SH;Yang, YD;Fang, Q;Shen, YZ;Xi, XM;Gu, Q;Zhou, XM;...

摘要:BACKGROUND During the spring of 2013, a novel avian-origin influenza A (H7N9) virus emerged and spread among humans in China. Data were lacking on the clinical characteristics of the infections caused by this virus. METHODS Using medical charts, we collected data on 111 patients with laboratory-confirmed avian-origin influenza A (H7N9) infection through May 10, 2013. RESULTS Of the 111 patients we...

5.Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers

作者机构:[Jin, Lian; Liu, Ming; Deng, Yan; He, Nongyue] Southeast Univ, Sch Biol Sci & Med Engn, State Key La...

通讯作者:Jin, L;Zeng, X;Liu, M;Deng, Y;He, NY

关键词:Non-viral; Gene delivery; Vectors; Chemical Methods

摘要:Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimi...

6.Wnt/beta-Catenin Signaling Promotes Renal Interstitial Fibrosis

作者机构:[He, Weichun; Dai, Chunsun; Li, Yingjian; Zeng, Gang; Monga, Satdarshan P.; Liu, Youhua] Univ Pittsb...

通讯作者:He, WC;Dai, CS;Li, YJ;Zeng, G;Monga, SP;Liu, YH

摘要:Writs compose a family of signaling proteins that play an essential role in kidney development, but their expression in adult kidney is thought to be silenced. Here, we analyzed the expression and regulation of Writs and their receptors and antagonists in normal and fibrotic kidneys after obstructive injury. In the normal mouse kidney, the vast majority of 19 different Writs and 10 frizzled recept...

7.PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

作者机构:[Jiang, Bing-Hua; Liu, Ling-Zhi] W Virginia Univ, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 ...

通讯作者:Jiang, BH;Liu, LZ

摘要:Phosphatidylinositol 3-kinase (PI3K) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular functions such as cell metabolism, proliferation, cell-cycle progression, and survival. PI3K is activated by growth factors and angiogenesis inducers such is vascular endothelial growth factor (VEGF) and angiopoietins. The amplificati...

8.Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma

作者机构:[Li, Li-Min; Chen, Xi; Zhang, Jun-Feng; Zhang, Chen-Yu; Zen, Ke] Nanjing Univ, Sch Life Sci, Inst Vi...

通讯作者:Li, LM;Hu, ZB;Zhou, ZX;Chen, X;Liu, FY;Zhang, JF;Shen, HB;Zhang, CY;Zen, K

摘要:Diagnosis of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), particularly HCC independent of cirrhosis etiology, presents a great challenge because of a lack of biomarkers. Here we test the hypothesis that expression profiles of microRNAs (miRNAs) in serum can serve as biomarkers for diagnosis of HBV infection and HBV-positive HCC. We recruited 513 subjects (210 controls and 135 H...

9.Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer

作者机构:[Liu, Rui; Chen, Xi; Wang, Cheng; Zhuang, Rui; Zen, Ke; Ba, Yi; Zhang, Chen-Yu] Tianjin Med Univ, Ca...

通讯作者:Liu, R;Chen, X;Du, YQ;Yao, WY;Shen, L;Wang, C;Hu, ZB;Zhuang, R;Ning, G;Zhang, CN;Yuan, YZ;Li, ZS;Zen...

摘要:BACKGROUND: Detection of pancreatic cancer (PaC), particularly at early stages, remains a great challenge owing to lack of specific biomarkers. We sought to identify a PaC-specific serum microRNA (miRNA) expression profile and test its specificity and sensitivity as a biomarker in the diagnosis and prognosis of PaC. METHODS: We obtained serum samples from 197 PaC cases and 158 age-and sex-matched ...

10.Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

作者机构:[Zhou, Xuan; Xu, Peng; Wang, Guangxiu; Jia, Zhifan; Pu, Peiyu; Kang, Chunsheng] Tianjin Med Univ, Ge...

通讯作者:Zhou, X;Ren, Y;Moore, L;Mei, M;You, YP;Xu, P;Wang, BL;Wang, GX;Jia, ZF;Pu, PY;Zhang, W;Kang, CS

关键词:miR-21; glioma; PTEN; Akt; EGFR

摘要:MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that regulate gene expression after transcription. Aberrant expression of miRNAs has been shown to be involved in tumorigenesis. We showed that miR-21 was one of the most frequently overexpressed miRNA in human glioblastoma (GBM) cell lines. To explore whether miR-21 can serve as a therapeutic target for glioblastoma, we downregulat...

11.Expression Profile of MicroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma

作者机构:[Zhang, Chunni; Wang, Cheng; Yang, Cuihua; Li, Ke; Wang, Junjun; Yang, Chen] Nanjing Univ, Dept Clin...

通讯作者:Zhang, CN;Wang, C;Chen, X;Yang, CH;Li, K;Wang, JJ;Dai, JC;Hu, ZB;Zhou, XJ;Chen, LB;Zhang, YN;Li, YF;...

摘要:BACKGROUND: Sensitive and specific biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC) are urgently needed to reduce the high morbidity and mortality of the disease. The discovery of serum microRNAs (miRNAs) and their unique concentration profiles in patients with various diseases makes them attractive, novel noninvasive biomarkers for tumor diagnosis. In this study, we...

12.CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea

作者机构:[McEvoy, R. Doug; Antic, Nick A.] Flinders Univ S Australia, Adelaide Inst Sleep Hlth, Adelaide, SA,...

通讯作者:McEvoy, RD;Antic, NA;Heeley, E;Luo, YM;Ou, Q;Zhang, XL;Mediano, O;Chen, R;Drager, LF;Liu, ZH;Chen, G...

摘要:BACKGROUND Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment with continuous positive airway pressure ( CPAP) prevents major cardiovascular events is uncertain. METHODS After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to-severe o...

13.Pre-Pregnancy Body Mass Index in Relation to Infant Birth Weight and Offspring Overweight/Obesity: A Systematic Review and Meta-Analysis

作者机构:[Yu, Zhangbin; Han, Shuping; Zhu, Jingai; Sun, Xiaofan; Ji, Chenbo; Guo, Xirong] Nanjing Med Univ, N...

通讯作者:Yu, ZB;Han, SP;Zhu, JG;Sun, XF;Ji, CB;Guo, XR

摘要:Background: Overweight/obesity in women of childbearing age is a serious public-health problem. In China, the incidence of maternal overweight/obesity has been increasing. However, there is not a meta-analysis to determine if pre-pregnancy body mass index (BMI) is related to infant birth weight (BW) and offspring overweight/obesity. Methods: Three electronic bibliographic databases (MEDLINE, EMBAS...

14.Birth weight and subsequent risk of obesity: a systematic review and meta-analysis

作者机构:[Yu, Z. B.; Han, S. P.; Zhu, G. Z.; Zhu, C.; Wang, X. J.; Cao, X. G.; Guo, X. R.] Nanjing Med Univ, ...

通讯作者:Yu, ZB;Han, SP;Zhu, GZ;Zhu, C;Wang, XJ;Cao, XG;Guo, XR

关键词:Birth weight; meta-analysis; obesity; systematic review

摘要:This report describes the association between birth weight (BW) and obesity. Screening of 478 citations from five electronic databases resulted in the inclusion of 33 studies, most of medium quality. The meta-analysis included 20 of these published studies. The 13 remaining articles did not provide sufficient dichotomous data and were systematically reviewed, revealing results consistent with the ...

15.miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

作者机构:[Zhu, Wei; Wang, Tongshan; Shu, Yongqian; Liu, Ping] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol...

通讯作者:Zhu, W;Shan, X;Wang, TS;Shu, YQ;Liu, P

关键词:microRNA; miR-181b; human cancer; multidrug resistance; BCL2

摘要:MicroRNAs (miRNAs) are short noncoding RNA molecules, which posttranscriptionally regulate genes expression and play crucial roles in diverse biological processes, such as development, differentiation, apoptosis and proliferation. Here, we investigated the possible role of miRNAs in the development of multidrug resistance (MDR) in human gastric and lung cancer cell lines. We found that miR-181b wa...

16.Long noncoding RNA: an emerging paradigm of cancer research

作者机构:[Qiu, Man-Tang] Nanjing Med Univ, Clin Coll 4, Nanjing 210009, Jiangsu, Peoples R China.;[Hu, Jing-W...

通讯作者:Qiu, MT;Hu, JW;Yin, R;Xu, L

关键词:Long noncoding RNA; Cancer; HOTAIR; MALAT1; HULC

摘要:Recent studies have demonstrated the importance of non-protein coding part of human genome in carcinogenesis and metastasis. Among numerous kinds of non-protein coding RNAs, long noncoding RNAs (lncRNAs) play a key regulatory role in cancer biology. LncRNAs are dysregulated in different kinds of cancer and the expression levels of certain lncRNAs are associated with recurrence, metastasis, and pro...

17.Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer

作者机构:[Li, Dan; Zhao, Yulan; Chen, Xiaona; Jiang, Yue; Zou, Chao; Zhang, Xiaolong; Liu, Shunying; Zhao, Da...

通讯作者:Li, D;Zhao, YL;Liu, CX;Chen, XN;Qi, YT;Jiang, Y;Zou, C;Zhang, XL;Liu, SY;Wang, XJ;Zhao, D;Sun, QA;Ze...

摘要:Purpose: To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in breast cancer. Experimental Design: The expression patterns of miR-195 and miR-497 were initially examined in breast cancer tissues and cell lines by Northern blotting and quantitative real-time PCR. Combined bisulfite restriction analysis and bisulfite sequencing were carried out to study the DNA ...

18.Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure

作者机构:[Packer, Milton] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA.;[McMurray, John ...

通讯作者:Packer, M;McMurray, JJV;Desai, AS;Gong, J;Lefkowitz, MP;Rizkala, AR;Rouleau, JL;Shi, VC;Solomon, SD;...

关键词:heart failure; neprilysin; receptors, angiotensin

摘要:Background-Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. Methods and Results-We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensin-converting enzyme inhibitor en...

19.Apatinib for Chemotherapy-Refractory Advanced Metastatic Gastric Cancer: Results From a Randomized, Placebo-Controlled, Parallel-Arm, Phase II Trial

作者机构:[Li, Jin; Guo, Weijian; Zhu, Xiaodong; Ji, Dongmei; Liu, Xin] Fudan Univ, Shanghai Canc Ctr, Shangha...

通讯作者:Li, J;Qin, SK;Xu, JM;Guo, WJ;Xiong, JP;Bai, YX;Sun, GP;Yang, Y;Wang, LW;Xu, N;Cheng, Y;Wang, ZH;Zhen...

摘要:Purpose Patients with metastatic gastric cancer (mGC) who do not respond to or who experience progression with second-line chemotherapy have no treatment options that clearly confer a survival benefit. This trial investigated the safety and efficacy of apatinib, an inhibitor of vascular endothelial growth factor receptor, as a treatment option for heavily pretreated patients with mGC. Patients and...

20.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression

作者机构:[Lu, Kai-hua; Li, Wei; Zhang, Mei-ling; Wu, Wei-qin] Nanjing Med Univ, Dept Oncol, Affiliated Hosp 1...

通讯作者:Lu, KH;Li, W;Liu, XH;Sun, M;Zhang, ML;Wu, WQ;Xie, WP;Hou, YY

关键词:Long non-coding RNA; MEG3; NSCLC; Proliferation; p53

摘要:Background: Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation of their biological functions and molecular mechanisms are important for understanding the development and progression of cancer. Recently, the downregulation of lncRNA MEG3 has been observed in various human cancers. However, its role in non-small cell lun...

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