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1.Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis

作者机构:[Tan, Chen-Chen; Yu, Jin-Tai; Meng, Xiang-Fei; Wang, Chong; Tan, Lan] Qingdao Univ, Qingdao Municipa...

通讯作者:Tan, CC;Yu, JT;Wang, HF;Tan, MS;Meng, XF;Wang, C;Jiang, T;Zhu, XC;Tan, L

关键词:Alzheimer's disease; donepezil; efficacy; galantamine; memantine;;meta-analysis; rivastigmine; safet...

摘要:Background: The role of currently available drugs for Alzheimer's disease (AD) has been controversial, with some national formularies restricting their use, and health economists questioning whether the small clinical effects are economically worthwhile. Objective: To estimate the efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of AD. Methods: Double-bl...

2.Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

作者机构:[Tan, Chen-Chen; Yu, Jin-Tai; Tan, Lan] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Neurol, ...

通讯作者:Tan, CC;Yu, JT;Tan, MS;Jiang, T;Zhu, XC;Tan, L

关键词:Autophagy; Aging; Alzheimer's disease; Parkinson's disease; Huntington's;disease; Amyotrophic latera...

摘要:Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and molecular pathogenetic mechanism involving aberrant misfolded protein or peptide aggregation and deposition. Autophagy represents a major route for degradation of aggregated cellular proteins and dysfunctional organelles. Emerging studies...

3.Anti-Inflammatory Drugs and Risk of Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis

作者机构:[Wang, Jun; Tan, Lan; Tan, Chen-Chen; Meng, Xiang-Fei; Wang, Chong; Yu, Jin-Tai] Qingdao Univ, Dept ...

通讯作者:Wang, J;Tan, L;Wang, HF;Tan, CC;Meng, XF;Wang, C;Tang, SW;Yu, JT

关键词:Alzheimer's disease; anti-inflammatory drug; aspirin; meta-analysis;;NSAIDs; prevention; systematic ...

摘要:Background: In the past 20 years, substantial evidence from laboratory and epidemiologic studies have suggested that anti-inflammatory medications could defer or prevent the occurrence of Alzheimer's disease (AD). However, several studies do not corroborate these findings. Objective: To evaluate the association of anti-inflammatory drug use on the incidence of AD. Methods: Pubmed, Embase, and Coch...

4.MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease

作者机构:[Zhou, Yan; Lu, Ming; Du, Ren-Hong; Qiao, Chen; Jiang, Chun-Yi; Ding, Jian-Hua; Hu, Gang] Nanjing Me...

通讯作者:Zhou, Y;Lu, M;Du, RH;Qiao, C;Jiang, CY;Zhang, KZ;Ding, JH;Hu, G

关键词:microRNA-7; NLRP3 inflammasome; alpha-Synuclein; Neuroinflammation;;Parkinson's disease

摘要:Background: alpha-Synuclein (alpha-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production of interleukin-1 beta in a process that depends, at least in vitro, on nod-like receptor protein 3 (NLRP3) inflammasome in monocytes. However, the role of NLRP3 inflammasome activation in the onset of PD has not yet been fully established. Results: In this stud...

5.Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

作者机构:[Muraro, Paolo A.] Imperial Coll London, Div Brain Sci, 160 Du Cane Rd,Burlington Danes Bldg,Fourth ...

通讯作者:Muraro, PA;Pasquini, M;Atkins, HL;Bowen, JD;Farge, D;Fassas, A;Freedman, MS;Georges, GE;Gualandi, F;...

摘要:IMPORTANCE Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies. OBJECTIVE To evaluate the long-term outcomes in patients who underwent AHSCT for the treatment of MS in a large multicenter cohort. DESIGN, SETTING, AND PARTICIPANTS Data were obtained in a multicenter, observational, retr...

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