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1.Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis

作者机构:[Gao, Wen; Shen, Hua; Li, Xiaodong; Shu, Yongqian] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, ...

通讯作者:Gao, W;Yu, Y;Cao, HL;Shen, H;Li, XD;Pan, SY;Shu, YQ

关键词:MicroRNA; Microarray; qRT-PCR; Non small cell lung cancer; Prognosis

摘要:Context - MicroRNAs (miRNAs) represent a class of small non-coding RNAs that regulate the gene expressions at the posttranscriptional level, subsequently control crucial physiological processes. Recent evidence demonstrates that some miRNAs have the functions similar to oncogene or tumor suppressors, It may play important roles in tumorigenesis MiRNA expression profiles may become useful biomarker...

2.The emerging problem of linezolid-resistant Staphylococcus

作者机构:[Gu, Bing; Hindler, Janet; Humphries, Romney M.] Univ Calif Los Angeles, David Geffen Sch Med, Dept ...

通讯作者:Gu, B;Kelesidis, T;Tsiodras, S;Hindler, J;Humphries, RM

关键词:antimicrobial resistance; staphylococci; MRSA; coagulase-negative;Staphylococcus; healthcare-associa...

摘要:The oxazolidinone antibiotic linezolid has demonstrated potent antimicrobial activity against Gram-positive bacterial pathogens, including methicillin-resistant staphylococci. This article systematically reviews the published literature for reports of linezolid-resistant Staphylococcus (LRS) infections to identify epidemiological, microbiological and clinical features for these infections. Linezol...

3.Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

作者机构:[Jiang, Teng; Yu, Jin-Tai; Zhu, Xi-Chen; Wang, Hui-Fu; Cao, Lei; Tan, Lan] Nanjing Med Univ, Qingdao...

通讯作者:Jiang, T;Yu, JT;Zhu, XC;Wang, HF;Tan, MS;Cao, L;Zhang, QQ;Gao, L;Shi, JQ;Zhang, YD;Tan, L

关键词:metformin; autophagy; stroke; preconditioning; AMPK; neuroprotection

摘要:Background and Purpose Recent clinical trials report that metformin, an activator of AMP-activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk of stroke by actions that are independent of its glucose-lowering effects. However, the underlying molecular mechanisms are not known. Here, we tested the possibility that acute metformin preconditioning confers neuro...

4.Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles

作者机构:[Yan, Fei; Wu, Hao; Liu, Hongmei; Liu, Xin; Zheng, Hairong] Southern Med Univ, Affiliated Hosp 3, De...

通讯作者:Yan, F;Wu, H;Liu, HM;Deng, ZT;Liu, H;Duan, WL;Liu, X;Zheng, HR

关键词:Theranostic nanoparticles; Imaging-guided therapy; iRGD; Indocyanine;green; Phototherapy

摘要:Multifunctional near-infrared (NIR) nanoparticles demonstrate great potential in tumor theranostic applications. To achieve the sensitive detection and effective phototherapy in the early stage of tumor genesis, it is highly desirable to improve the targeting of NIR theranostic agents to biomarkers and to enhance their accumulation in tumor. Here we report a novel targeted multifunctional theranos...

5.Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer

作者机构:[Zhu, Mingchen; Chen, Yun] Nanjing Med Univ, Sch Pharm, 818 Tian Yuan East Rd, Nanjing 211166, Jiang...

通讯作者:Zhu, MC;Xu, YJ;Chen, Y;Yan, F

关键词:Colorectal cancer; Circular RNA; BANP; Proliferation; siRNA

摘要:Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human cir...

6.The use of lncRNA analysis for stratification management of prognostic risk in patients with NSCLC

作者机构:[Zhang, C. -G.] Nanjing Med Univ, Dept Oncol, Affiliated Hosp 2, Nanjing, Jiangsu, Peoples R China.;...

通讯作者:Zhang, CG;Yin, DD;Sun, SY;Han, L

关键词:Non-small cell lung cancer (NSCLC); Long noncoding RNAs (lncRNAs);;Disease-free survival time (DFS)

摘要:OBJECTIVE: Lung cancer is the most frequent cancer in China and worldwide. Long noncoding RNAs (lncRNAs) have been shown to play important regulatory roles in human cancer biology. The aim of the present study was to investigate the relationship between genomics and prognosis among lung cancer patients. PATIENTS AND METHODS: We collected specimens from non-small cell lung cancer (NSCLC) patients a...

7.Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/beta-catenin and Sonic Hedgehog Pathways

作者机构:[Zhu, Jian-Yun; Yang, Xue; Chen, Yue; Jiang, Ye; Wang, Shi-Jia; Li, Yuan; Wang, Xiao-Qian; Meng, Yu;...

通讯作者:Zhu, JY;Yang, X;Chen, Y;Jiang, Y;Wang, SJ;Li, Y;Wang, XQ;Meng, Y;Zhu, MM;Ma, X;Huang, C;Wu, R;Xie, C...

关键词:lung cancer stem cells; curcumin; Wnt/beta-catenin pathway; Sonic;Hedgehog pathway; inhibition

摘要:Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus, targeting CSCs may be a promising strategy for cancer therapy. Wnt/beta-catenin and Sonic Hedgehog pathways play an important regulatory role in maintaining CSC characteristics. Natural compounds, such as curcumin, possess chemopreventive properties. However, the interventional effect of curcumin on lung CSCs...

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