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1.A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptiblility of Lung Cancer in Chinese

作者机构:[Tian, Tian; Chen, Jiaping; Hu, Zhibin; Jin, Guangfu; Liang, Jie; Zhou, Xiaoyi; Miao, Ruifen; Ma, Ho...

通讯作者:Tian, T;Shu, YQ;Chen, JP;Hu, ZB;Xu, L;Jin, GF;Liang, J;Liu, P;Zhou, XY;Miao, RF;Ma, HX;Chen, YJ;Shen...

摘要:microRNAs (miRNA) are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes,. They participate in diverse biological pathways and function as gene regulators. Recently, we conducted a survey of common single nucleotide polymorphisms (SNP) in miRNA sequences and reported that, among four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs, rs1...

2.Circulating Tumor DNA Is Effective for the Detection of EGFR Mutation in Non-Small Cell Lung Cancer: A Meta-analysis

作者机构:[Qiu, Mantang; Wang, Jie; Xu, Youtao; Ding, Xiangxiang; Li, Ming; Jiang, Feng; Xu, Lin; Yin, Rong] N...

通讯作者:Qiu, MT;Wang, J;Xu, YT;Ding, XX;Li, M;Jiang, F;Xu, L;Yin, R

摘要:Background: Circulating tumor DNA (ctDNA) has offered a minimally invasive and feasible approach for detection of EGFR mutation for non-small cell lung cancer (NSCLC). This meta-analysis was designed to investigate the diagnostic value of ctDNA, compared with current "gold standard," tumor tissues. Methods: We searched PubMed, EMBASE, Cochrane Library, and Web of Science to identify eligible studi...

3.The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

作者机构:[Amos, Christopher I.; Byun, Jinyoung; Li, Yafang; Xiao, Xiangjun; Kamal, Ahsan; Forman, Judith L.] ...

通讯作者:Amos, CI;Dennis, J;Wang, ZM;Byun, J;Schumacher, FR;Gayther, SA;Casey, G;Hunter, DJ;Sellers, TA;Grube...

摘要:Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping ...

4.Ethical Issues in Fecal Microbiota Transplantation in Practice

作者机构:[Ma, Yonghui] Xiamen Univ, Xiamen, Peoples R China.;[Liu, Jiayu] Yale Univ, New Haven, CT 06520 USA....

通讯作者:Ma, YH;Liu, JY;Rhodes, C;Nie, YZ;Zhang, FM

关键词:confidential; fecal microbiota transplantation; privacy; risk; benefit;analysis; vulnerability

摘要:Fecal microbiota transplantation (FMT) has demonstrated efficacy and is increasingly being used in the treatment of patients with recurrent Clostridium difficile infection. Despite a lack of high-quality trials to provide more information on the long-term effects of FMT, there has been great enthusiasm about the potential for expanding its applications. However, FMT presents many serious ethical a...

5.Six Serum-Based miRNAs as Potential Diagnostic Biomarkers for Gastric Cancer

作者机构:[Huang, Zebo; Zhou, Xin; Zhang, Lan; Zhang, Huo; Zhu, Wei; Shu, Yongqian; Liu, Ping] Nanjing Med Uni...

通讯作者:Huang, ZB;Zhu, DX;Wu, LR;He, MF;Zhou, X;Zhang, L;Zhang, H;Wang, WW;Zhu, J;Cheng, WF;Chen, Y;Fan, Y;Q...

摘要:Background: Circulating miRNAs in serum may serve as promising diagnostic biomarkers for patients with gastric cancer. Methods: Using qRT-PCR-based Exiqon panel, we identified 58 differentially expressed miRNAs from three gastric cancer pool samples and one normal control (NC) pool in the initial screening phase. Identified miRNAs were further validated in the training (49 gastric cancer vs. 47 NC...

6.The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

作者机构:[Amos, Christopher I.; Byun, Jinyoung; Li, Yafang; Xiao, Xiangjun; Kamal, Ahsan; Forman, Judith L.] ...

通讯作者:Amos, CI;Dennis, J;Wang, ZM;Byun, J;Schumacher, FR;Gayther, SA;Casey, G;Hunter, DJ;Sellers, TA;Grube...

摘要:Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping ...

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